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ホーム  > 教員情報カテゴリ  > た行  > 竹嶋 伸之輔

竹嶋 伸之輔

人間生活学部 食物栄養学科 教授
竹嶋 伸之輔(たけしま しんのすけ)

担当講義科目名

解剖生理学/実習
病原物質・微生物学/実習
免疫学(発達心理学科)

講義内容

解剖生理学/実習
人体のしくみを構造と機能の密接な関連の元に理解する
病原物質・微生物学/実習
微生物の分類や病原性を理解し、細菌の染色法や培養法を学ぶ
免疫学
免疫の基礎とアレルギーについて学ぶ

研究分野

微生物学      免疫学
ゲノム科学     畜産学

所属学会

日本獣医学会(評議員)日本主要組織適合学会(評議員)動物遺伝育種学会

学歴

1990年私立市川学園高等学校 卒業
1996年東北大学農学部畜産学科 卒業
2001年東北大学大学院農学研究科畜産学専攻博士課程 修了

経歴

1998-2001年
理化学研究所 ジュニア・リサーチ・アソシエイト
2001-2011年
理化学研究所 協力研究員
2011-2012年
理化学研究所 基幹研究所研究員
2012-2017年
理化学研究所 研究員
2011-2017年
兼・東京大学大学院メディカルゲノム専攻 連携准教授
2015-2017年
兼・十文字学園女子大学 非常勤講師
2017-2018年
兼・東京農工大農学部 特任教授
2018年
十文字学園女子大学 教授
2018年
兼・東京農工大農学部感染症センター 参与研究員
2018年
兼・理化学研究所 客員研究員

学位・資格

博士(農学)

最近のおもな業績

原著論文

Takeshima SN, Corbi-Botto C, Giovambattista G, Aida Y: Genetic Diversity of BoLA-DRB3 in South American Zebu Cattle Populations. BMC Genetics, in press.
Polat M., Takeshima SN, Aida Y: Epidemiology and genetic diversity of bovine leukemia virus. Virology Journal 2017, 14:209
Takeshima SN, Sasaki S, Polat M, Sugimoto Y, Aida Y: Single nucleotide polymorphisms in the bovine MHC region of Japanese Black cattle are associated with bovine leukemia virus proviral load. Retrovirology 2017, 14:24
Polat M, Moe HH, Shimogiri T, Moe KK, Takeshima SN, Aida Y: The molecular epidemiological study of bovine leukemia virus infection in Myanmar cattle. Arch Virol 2016.
Polat M, Takeshima SN, Hosomichi K, Kim J, Miyasaka T, Yamada K, Arainga M, Murakami T, Matsumoto Y, de la Barra Diaz V, et al: A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis. Retrovirology 2016, 13:4.
Takeshima SN, Watanuki S, Ishizaki H, Matoba K, Aida Y: Development of a direct blood-based PCR system to detect BLV provirus using CoCoMo primers. Arch Virol 2016, 161:1539-1546.
Matsubara T, Nishii N, Takashima S, Takasu M, Imaeda N, Aiki-Oshimo K, Yamazoe K, Kakisaka M, Takeshima SN, Aida Y, et al: Identification and characterization of two CD4 alleles in Microminipigs. BMC Vet Res 2016, 12:222.
Bai L, Takeshima SN, Isogai E, Kohara J, Aida Y: Novel CD8(+) cytotoxic T cell epitopes in bovine leukemia virus with cattle. Vaccine 2015, 33:7194-7202.
Bai L, Otsuki H, Sato H, Kohara J, Isogai E, Takeshima SN, Aida Y: Identification and characterization of common B cell epitope in bovine leukemia virus via high-throughput peptide screening system in infected cattle. Retrovirology 2015, 12:106.
Ohno A, Takeshima SN, Matsumoto Y, Aida Y: Risk factors associated with increased bovine leukemia virus proviral load in infected cattle in Japan from 2012 to 2014. Virus Res 2015, 210:283-290.
Polat M, Ohno A, Takeshima SN, Kim J, Kikuya M, Matsumoto Y, Mingala CN, Onuma M, Aida Y: Detection and molecular characterization of bovine leukemia virus in Philippine cattle. Arch Virol 2015, 160:285-296.
Takeshima SN, Giovambattista G, Okimoto N, Matsumoto Y, Rogberg-Munoz A, Acosta TJ, Onuma M, Aida Y: Characterization of bovine MHC class II DRB3 diversity in South American Holstein cattle populations. Tissue Antigens 2015, 86:419-430.
Takeshima SN, Kitamura-Muramatsu Y, Yuan Y, Polat M, Saito S, Aida Y: BLV-CoCoMo-qPCR-2: improvements to the BLV-CoCoMo-qPCR assay for bovine leukemia virus by reducing primer degeneracy and constructing an optimal standard curve. Arch Virol 2015, 160:1325-1332.
Takeshima SN, Miyasaka T, Matsumoto Y, Xue G, Diaz Vde L, Rogberg-Munoz A, Giovambattista G, Ortiz M, Oltra J, Kanemaki M, et al: Assessment of biodiversity in Chilean cattle using the distribution of major histocompatibility complex class II BoLA-DRB3 allele. Tissue Antigens 2015, 85:35-44.
Yuan Y, Kitamura-Muramatsu Y, Saito S, Ishizaki H, Nakano M, Haga S, Matoba K, Ohno A, Murakami H, Takeshima SN, Aida Y: Detection of the BLV provirus from nasal secretion and saliva samples using BLV-CoCoMo-qPCR-2: Comparison with blood samples from the same cattle. Virus Res 2015, 210:248-254.
Polat M, Aida Y, Takeshima SN, Aniwashi J, Halik M: The diversity of major histocompatibility complex class II DRB1 gene in sheep breeds from Xinjiang, China. Tissue Antigens 2015, 85:50-57.
Hagiwara K, Ishii H, Murakami T, Takeshima SN, Chutiwitoonchai N, Kodama EN, Kawaji K, Kondoh Y, Honda K, Osada H, et al: Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor. PLoS One 2015, 10:e0145573.
Goszczynski DE, Ripoli MV, Takeshima SN, Baltian L, Aida Y, Giovambattista G: Haplotype determination of the upstream regulatory region and the second exon of the BoLA-DRB3 gene in Holstein cattle. Tissue Antigens 2014, 83:180-183.
He P, Takeshima SN, Tada S, Akaike T, Ito Y, Aida Y: pH-sensitive carbonate apatite nanoparticles as DNA vaccine carriers enhance humoral and cellular immunity. Vaccine 2014, 32:6199-6205.
Takeshima SN, Miyasaka T, Polat M, Kikuya M, Matsumoto Y, Mingala CN, Villanueva MA, Salces AJ, Onuma M, Aida Y: The great diversity of major histocompatibility complex class II genes in Philippine native cattle. Meta Gene 2014, 2:176-190.
Zahoor MA, Xue G, Sato H, Murakami T, Takeshima SN, Aida Y: HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages. PLoS One 2014, 9:e106418.
Giovambattista G, Takeshima SN, Ripoli MV, Matsumoto Y, Franco LA, Saito H, Onuma M, Aida Y: Characterization of bovine MHC DRB3 diversity in Latin American Creole cattle breeds. Gene 2013, 519:150-158.
Miyasaka T, Takeshima SN, Jimba M, Matsumoto Y, Kobayashi N, Matsuhashi T, Sentsui H, Aida Y: Identification of bovine leukocyte antigen class II haplotypes associated with variations in bovine leukemia virus proviral load in Japanese Black cattle. Tissue Antigens 2013, 81:72-82.
Takeshima SN, Panei CJ, Omori T, Nunoya T, Davis WC, Ishizaki H, Matoba K, Aida Y: Estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis using BLV-CoCoMo-qPCR. BMC Vet Res 2013, 9:95.

著書

間陽子・竹嶋伸之輔:獣医免疫学ー獲得免疫における主要組織適合遺伝子複合体(MHC)と抗原提示細胞, 緑書房 2015
Aida Y, Takeshima SN, Baldwin CL, Kaushik AK: Bovine Immunogenetics. In The genetics of cattle. 2nd Edition edition. Edited by Garrick DJ, Ruvinsky A. USA: CAB International; 2014: 153

総説

竹嶋伸之輔, 大附寛幸、白らんらん、間陽子: 特集「牛白血病ウイルス(BLV)に対する理研の挑戦」BLVのワクチン開発. JVM 獣医畜産新報 2017, 70:909-916.
間陽子、竹嶋伸之輔, 陸拾七: 特集「牛白血病ウイルス(BLV)に対する理研の挑戦」BLV抵抗性・感受性の診断技術と新しい牛白血病制圧戦略. JVM獣医畜産新報 2017, 70:901-908.
白らんらん、佐藤洋隆、綿貫園子、竹嶋伸之輔, 間陽子: 特集「牛白血病ウイルス(BLV)に対する理研の挑戦」BLVの診断法の開発. JVM獣医畜産新報 2017, 70:894-900.
大附寛幸、間陽子、竹嶋伸之輔, 松浦僚介: 特集「牛白血病ウイルス(BLV)に対する理研の挑戦」 BLVの分子生物学とその応用. JVM獣医畜産新報 2017, 70:887-893.
竹嶋伸之輔, 綿貫園子, 間陽子: 牛白血病対策の新技術に迫る(3)BLV-CoCoMo-qPCR法によるBLV伝播リスクの評価. 臨床獣医 2017, 1:30-35.
竹嶋伸之輔, 竹嶋伸之輔, 綿貫園子, 間陽子: 牛白血病対策の新技術に迫る(2)BLV-CoCoMo-qPCR法によるBLV伝播リスクの評価. 臨床獣医 2016, 34:30-35.
竹嶋伸之輔, 竹嶋伸之輔, 綿貫園子, 間陽子: 牛白血病対策の新技術に迫る(1)BLV-CoCoMo-qPCR法によるBLVの診断とBLV伝播リスク因子の検索. 臨床獣医 2016, 34:34-40.
Aida Y, Murakami H, Takahashi M, Takeshima SN: Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus. Front Microbiol 2013, 4:328.

国際学会要旨

Ohno A, Takeshima S, Kikuya M, Matsumoto Y, Aida Y: Epidemiological features of BLV infection in Japan from 2012 to 2013. Retrovirology 2015, 12:P41.
Otsuki H, Takeshima S, Aida Y: Generation of virus-like particle as a vaccine strategy against bovine leukemia virus. Retrovirology 2015, 12:P47.
Bai L, Takeshima S, Ohno A, Matsumoto Y, Isogai E, Kohara J, Aida Y: Epitope mapping of CD8+T cells on bovine leukemia virus Gag, Env and Tax protein in cattle with different bovine MHC DRB3 alleles. Retrovirology 2015, 12:P49.
Bai LL, Takeshima S, Isogai E, Aida Y: Peptide microarray mapping of B cell epitopes on bovine leukemia virus and peptide ELISA analysis of conservation of epitopes in BLV infected Japanese cattle. Retrovirology 2015, 12:P97.
Takeshima S, Bai LL, He P, Matsumoto Y, Kohara J, Hirai T, Omori T, Nunoya T, Yamamoto Y, Hidaka T, et al: A novel bovine leukemia virus peptide vaccine targeting susceptible cattle-Estimating vaccine effectiveness using susceptible cattle constructed by fertilized ovum transplantation. Retrovirology 2015, 12:P50.
Aida Y, Kim J, Okimoto N, Yamagishi J, Tada S, Ito Y, Takeshima S: A novel bovine leukemia virus peptide vaccine targeting susceptible cattle-Production by 3-D modelling and nanotechnology. Retrovirology 2015, 12:P48.
Aida Y, Takeshima SN, Panei C, Omori T, Nunoya T, Davis W, Ishizaki H, Matoba K: BLV-CoCoMo-qPCR: estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis. Retrovirology 2014, 11:P143.

社会活動

日本獣医学会評議員
日本主要組織適合学会評議員

学科紹介